产品货号：
Z12659
中文名称：
CD10/MME抗体
英文名称：
Anti-CD10/MME Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CD10/MME Antibody |
| 指标别名 | Atriopeptidase;CALLA;CD10;Enkephalinase;EPN;membrane metallo endopeptidase;MME;MME;CD10;NEP;Neprilysin;Neutral endopeptidase;Neutral endopeptidase 24.11 |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | MME |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CD10 recombinant protein (Position:Y52-W750).Human CD10 shares 94% amino acid (aa) sequences identity with both mouse and rat CD10. |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CD10,also known as membrane metallo-endopeptidase,neutral endopeptidase(NEP),Neprilysin,or common acute lymphoblastic leukemia antigen(CALLA),is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides,most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease.This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization.By cDNA transfection analysis,CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase.CD10 has also been called atriopeptidase.Atriopeptidase specifically degrades atrial natriuretic factor.A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion.These effects include diuresis,natriuresis,vasodilatation,and suppression of the renin-angiotensin-aldosterone system. |
| Uniprot ID | P08473 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | membrane metallo-endopeptidase |
| 蛋白名全称 | Neprilysin |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 22 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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